Specifically, we (1) established a prognostic gene signature associated with immune escape in GBM, (2) validated its prognostic significance across independent GBM and LGG cohorts, (3) linked the signature to immune cell infiltration patterns using deconvolution algorithms, (4) resolved the cellular expression of signature genes using single-cell RNA sequencing, and (5) experimentally confirmed the tumor-promoting role of PPP1R8 using CRISPR/Cas9 knockout in GBM cells. The gene discussed is PPP1R8; the disease is glioblastoma.