A Methyltransferase-like 5 (METTL5) activates PKM2 transcription by upregulating Ubiquitin Specific Protease 5 (USP5) to inhibit c-Myc ubiquitin-mediated degradation (55), while downregulation of GATA6 drives metabolic reprogramming in HCC cells (56). Here, PKM is linked to hepatocellular carcinoma.