PKM and gastric cancer: Aerobic glycolysis is also precisely regulated at the epigenetic level-histone lysine methyltransferase SETD1A enhances HIF-1α recruitment to the PKM2 promoter through Histone H3 Lysine 4 (H3K4) methylation, forming a HIF-1α/SETD1A positive feedback loop that persistently amplifies glycolytic flux and sustains the continuous proliferation of gastric cancer cells (63).