CARM1 and breast carcinoma: In breast cancer, coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of PKM2 promotes its interaction with inositol 1,4,5-trisphosphate receptors (InsP3Rs), reducing endoplasmic reticulum to mitochondria Ca2+ flux and triggering aerobic glycolysis (32).