In triple-negative breast cancer (TNBC), PKM2 upregulates acyl-CoA dehydrogenase very long chain (ACADVL) through the AMP-activated protein kinase–Krüppel-like factor 4 (AMPK–KLF4) axis, promoting lipid β-oxidation while depleting lipid droplet storage. This evidence concerns the gene ACADVL and triple-negative breast carcinoma.