We classified a total of 7,759 tumor cells into separate subpopulations based on their DEGs and designated each cluster according to its most prominently expressed marker gene: C0 NAP1L1+ TCs, C1 CA2+ TCs, C2 MKI67+ TCs, and C3 ITLN1+ TCs (Figure 3A). The gene discussed is ITLN1; the disease is neoplasm.