It is noteworthy that in the mammalian target of rapamycin (mTOR) signaling pathway, the PI3K/AKT/mTOR axis plays a pivotal role, particularly mTOR complex 1 (mTORC1), which regulates the initiation of autophagy in acute pancreatitis (AP) through ULK1 phosphorylation (16). Here, MTOR is linked to acute pancreatitis.