By catalyzing the transamination of glutamate and oxaloacetate to produce aspartate and α-ketoglutarate, GOT2 ensures the availability of aspartate—essential for nucleotide biosynthesis and tumor cell proliferation—and supports the tricarboxylic acid (TCA) cycle via α-ketoglutarate anaplerosis, thereby sustaining mitochondrial energy metabolism (21–26). The gene discussed is GOT2; the disease is neoplasm.