Additionally, increased serum HMGB3 mRNA levels in bacterial Sepsis-Associated ALI patients, along with the involvement of the miR-424-5p/HMGB3 axis in sepsis-induced AEC inflammation and apoptosis (117), suggest that targeting HMGB proteins may offer a novel therapeutic approach for managing AEC dysfunction in sepsis. The gene discussed is HMGB3; the disease is acute respiratory distress syndrome.