In sepsis-mediated AEC injury, histone deacetylases Histone Deacetylase 3 (HDAC3) (60) and SIRT1 (69, 121) play key roles in regulating AEC autophagy, oxidative stress, mitochondrial dysfunction, and inflammatory factor release, thereby influencing AEC viability. This evidence concerns the gene HDAC3 and Sepsis.