SIRT1 and bacterial infectious disease with sepsis: In CLP or LPS-induced bacterial sepsis models, it was found that suppression of Sirtuin 1 (SIRT1) expression in AECs (69) or direct activation of the inflammasome (14) amplifies inflammatory signaling, triggering a cascade of cytokines and chemokines that further disrupt immune regulation and promote multi-organ dysfunction (30, 70).