Another study on the diagnostic accuracy of 123I-Ioflupane SPECT for the differentiation of FTD from dementia with Lewy bodies (DLB)21 showed that the uptake of striatal DAT is reduced in some cases of FTD and that 123I-Ioflupane SPECT is less useful in differentiating FTD from DLB than it is in differentiating AD from DLB. This evidence concerns the gene SLC6A3 and Alzheimer disease.