APOE and Alzheimer disease: Moreover, a variety of critical genes including MECP2 (Methyl-CpG Binding Protein 2) (Wen et al., 2017), PTEN (phosphatase and tensin homolog) (Zhou and Parada, 2012), APOE (apolipoprotein E) (Husain et al., 2021), AKAP9 (A-kinase anchoring protein 9) (Poelmans et al., 2013), SLC6A4 [solute carrier family 6 (neurotransmitter transporter, serotonin), member 4] (Calabrò et al., 2020) and etc. have been reported to play vital roles in both ASD and AD.