S100A14 and cholesteryl ester measurement: We performed RT-qPCR experiments to verify the RNA-seq data and assessed the expressions of CADPS, CPT1B, S100A14, KLK5, LDHA, RLP4, and UBC genes in each of the 72 originally collected CE samples (Supplementary Table S1 shows the primer sequences and annealing temperatures; Supplementary Table S17 contains the obtained Ct values).