We identified somatic and germline GOF variants in TLR8 presenting with inflammation, neutropenia, bone marrow failure, lymphoproliferation, caused by TLR8 (INFLTR8), which has additional presentations of antibody deficiency, CD8 T cell dysregulation, and in some cases large granular lymphocytic leukemia (106). This evidence concerns the gene TLR8 and agammaglobulinemia.