For example, COPA syndrome, arising from variants in COPA that encodes an ER transport protein, and STING-associated vasculopathy with onset in infancy (SAVI) both present with interstitial lung disease, but patients with COPA syndrome often have alveolar hemorrhage, which is only seen in a handful of patients with SAVI syndrome (131, 132, 133). Here, STING1 is linked to autoimmune interstitial lung disease-arthritis syndrome.