Indeed, in RA, IL-6, IL-1β, and TNF-α are pointed out in the literature as being overexpressed and correlate with systemic inflammation and blood-brain barrier (BBB) impairment, which may predispose to neurodegenerative diseases, such as late-onset Alzheimer’s disease (LOAD) and PD [11,12]. The gene discussed is TNF; the disease is Parkinson disease.