NR3C1 and systemic lupus erythematosus: Cerebrovascular: antiphospholipid antibodies → hypercoagulation → stroke/cerebral microinfarction → cognitive decline. Autoantibodies: anti-N-methyl-D-aspartate (NMDA) receptors, antibodies → hippocampal/amygdala damage. Neuroanatomical: hippocampal/cortical atrophy linked to SLE duration/autoantibodies. Steroid use: glucocorticoid receptor effects on memory/cognition.