PPARG and systemic lupus erythematosus: In the case of autoimmune diseases, such as SLE, it is suggested to implement steroid-sparing treatments and vascular risk factor management (e.g., control blood pressure) to decrease the risk of dementia [18], and NSAIDs (e.g., ibuprofen) could be neuroprotective in PD through peroxisome proliferator-activated receptor gamma (PPARγ) signaling [19].