To explore the causal relationship between these metabolite‐related genes and calculus of kidney and ureter, we performed SMR analysis using eQTL data from the eQTLgen Consortium, and 21 genes related to calculus of kidney and ureter were found, including CLDN10, OGFOD2, GGT1, MPEG1, HNF1A, CELF2, ARL15, RIBC2, CSNK1G3, LAMA2, and others (Figure 7A). This evidence concerns the gene OGFOD2 and urolithiasis.