Plumbagin has been shown to reduce MMP‐2 and uPA (Jaiswal et al. 2002; Shih et al. 2009) levels, preventing the migration and infiltration of HepG2 cells in liver cancer cells, it leads toinhibiting the growing liver cancer cells p300, located in close proximity to lysine acetyltransferase, is associated with numerous diseases due to its dysfunction, and it controls multiple genes. This evidence concerns the gene EP300 and liver cancer.