Transgenic flies expressing human Aβ peptides or mutant tau proteins under tissues-specific promoters, develop progressive neurodegeneration, memory impairments, locomotors deficits, and reduced lifespan-phenotypes that mirror key aspects of AD (Bongiorni et al., 2024; Elovsson et al., 2024; Yang et al., 2024). The gene discussed is MAPT; the disease is Alzheimer disease.