Other known risk factors for the development of Alzheimer’s disease include age >65 years, presence of the epsilon 4 allele of the apolipoprotein E (apoE) gene, female sex, diabetes mellitus, arterial hypertension, smoking, obesity, low levels of high-density lipoprotein cholesterol, hearing loss, traumatic brain damage, depression and social isolation, low physical activity, alcohol abuse, and air pollution (Knopman et al., 2021). Here, APOE is linked to Alzheimer disease.