As expected, higher baseline levels of CSF YKL-40 were also linked to more rapid atrophy in the volumes of whole brain (β = −0.001, p = 0.028), hippocampus (β = −0.003, p = 0.002), entorhinal cortex (β = −0.0002, p = 0.002) and middle temporal lobe (β = −0.002, p = 0.003) (Figure 4 and Supplementary Table 9 in Supplementary Material 1). The gene discussed is CHI3L1; the disease is Atrophy.