We also systematically reviewed the previous literature and found that previous studies frequently, but not consistently reported the relation of IL-6, IL-7, or IL-10 to AD biomarkers, neuroinflammation, cognitive performance, and brain structures (Cisbani et al., 2020; Hazen et al., 2020; Janelidze et al., 2018; Marsland et al., 2015). This evidence concerns the gene IL10 and Alzheimer disease.