More precisely, the associations between baseline levels of YKL-40 and longitudinal changes of FAQ (β = 0.631, p < 0.001), MEM (β = −0.305, p < 0.001), and AD signature ROI volume (whole brain: β = −0.001, p = 0.001; hippocampus: β = −0.004, p < 0.001; entorhinal cortex: β = −0.005, p < 0.001, and middle temporal lobe: β = −0.004, p < 0.001, respectively) were significant only in the HTN + subgroup (Supplementary Figure 2 and Supplementary Table 10 in Supplementary Material 1). This evidence concerns the gene CHI3L1 and Alzheimer disease.