Notably, the significant associations between the CSF levels of YKL-40 and p-tau, t-tau, or neuroinflammatory biomarkers were not moderated by factors such as hyperlipidemia, sex, age, APOEε4 status, or Aβ status (Supplementary Tables 4, 5 in Supplementary Material 1). This evidence concerns the gene MAPT and hyperlipidemia.