TSPO is upregulated in liver (Zhang et al., 2023), breast (Hardwick et al., 1999), and pancreatic cancers (Zhang et al., 2021), while significantly downregulated in colon and lung cancers (Bhoola et al., 2018), resulting in differential effects on the biological phenotype of tumor cells. This evidence concerns the gene TSPO and familial pancreatic carcinoma.