Interestingly, under SCI the knock-out of the SNCA gene resulted in neuroprotection and decreased pro-inflammatory factors (Sauerbeck et al., 2021), suggesting that indeed α-syn may be playing a role in the induction of astrocyte reactivity and neuroinflammation in response to insults not even related to α-synucleinopathies. The gene discussed is SNCA; the disease is synucleinopathy.