Familial genetic α-synucleinopathies are typically caused by abnormalities in the α-synuclein (α-syn) gene (SNCA), including duplication (Chartier-Harlin et al., 2004; Ibáñez et al., 2004), triplication (Singleton et al., 2003) or point mutations of the gene (Krüger et al., 2001; Polymeropoulos et al., 1997; Zarranz et al., 2004) that result in pathological structural modifications of the protein. Here, SNCA is linked to synucleinopathy.