In contrast, nigral neurons that contained α-syn-ir or tau-ir aggregates had a similar and significant reduction in CX3CL1 immunofluorescence intensity (66.36% for MMD-LB, 76.18% for PD, and 80.21% for PSP) versus nigral neurons without inclusions (p < 0.001). This evidence concerns the gene MAPT and Parkinson disease.