Next-generation sequencing of target genes in this patient’s tumor tissue detected gene variations, such as BTG2 (p.s110fs), PRDM1 (p.s276*), NOTCH2 (p.y2340S), ITPKB (p.a485v), TBL1XR (p.s459N), PAX5 (p.*392 W), and CIITA (p.p146S), which implicate nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB), NOTCH, ITPKB, Wnt/β-catenin, and EGFR signaling pathways. The gene discussed is CIITA; the disease is neoplasm.