Next, in univariable Cox proportional hazard analysis for ESKD, age (HR 1.025), BMI (HR 0.883), MPO-ANCA (or P-ANCA) positive (HR 2.747), haemoglobin (HR 0.664), blood urea nitrogen (HR 1.031), serum creatinine (HR 1.533), serum albumin (HR 0.580), hypertension (HR 2.380), and FFS + eVDI (HR 1.406) at AAV diagnosis exhibited the significant association with ESKD during follow-up (Supplementary Table 2). This evidence concerns the gene MPO and anti-neutrophil cytoplasmic antibody-associated vasculitis.