Case 1 (indeterminate glycemia) improved early insulin secretion, reducing glucose AUC by 12.35%.Case 2 (CFRD) increased insulin AUC by 77%, with glucose AUC reduced by 16%. Diabetes status improved from CFRD to indeterminate glycemia.Both patients showed enhanced glucose metabolism, with increased early-phase insulin secretion and better glycemic response to OGTT. This evidence concerns the gene INS and diabetes mellitus.