Shaoyao-Gancao decoction treatment can not only effectively reduce the phosphorylation of NF-κB p65, increase the expression of IκB, and decrease the levels of inflammatory factors such as TNF-α, IL-1β, IL-6 and IL-18 in the serum and ovarian tissues of PCOS rats (79), but also enhance the expression of tight junction proteins (occludin and claudin1) and inhibit the expression of key genes and proteins in the TLR4/NF-κB signaling pathway (49). Here, IL1B is linked to polycystic ovary syndrome.