A total of 18 RCTs (15 two-arm, 2 three-arm, and 1 four-arm) (33, 44, 49, 54, 66, 68, 76, 83, 93, 97, 103, 109, 110, 121, 126, 139–141) reported improvements in IL-6 outcome indicators for patients with T2DM and overweight or obesity. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.