IL6 and chorioamnionitis: FIRS is a systemic inflammatory condition affecting the fetus, characterized by elevated inflammatory mediators, particularly interleukin-6 (IL-6), in the fetal circulation, typically triggered by intra-amniotic infection, inflammation, or hypoxic stress; it's often considered a preclinical stage of neonatal sepsis and a marker of fetal distress due to infection or sterile inflammation (37).