Additionally, research carried by Bazzone has demonstrated that under the stimulation of encephalomyocarditis virus (EMCV) RNA, A Disintegrin and Metalloproteinase domain 9 (ADAM9) (a metalloproteinase) activates downstream MAVS by binding to MDA5 and promoting its oligomerization, thereby enhancing antiviral signaling during viral infection (11). Here, IFIH1 is linked to viral infectious disease.