Xu et al. found that TAX1BP1 inhibits the interaction between NLRP3 and MAVS by suppressing the localization of NLRP3 to mitochondria, thereby eliminating acute myocardial infarction-induced NLRP3 inflammasome activation and related mitochondrial dysfunction, ultimately alleviating myocardial infarction and cardiac dysfunction. Here, TAX1BP1 is linked to myocardial infarction.