Fang et al. uncovered that TRIM18 exerts exacerbation of viral myocarditis by recruiting protein phosphatase 1A (PPM1A) to dephosphorylate TANK-binding kinase 1 (TBK1), preventing TBK1 from interacting with its MAVS and STING, thereby inhibiting antiviral signaling transduction, and knockdown TRIM18 can reduce less cardiac inflammation (12). The gene discussed is TBK1; the disease is viral myocarditis.