Helper and regulatory T cells were identified by expression of CD4 and FOXP3 genes, and CD8POS T cells were marked by expression of CD8A/B. The CD8POS T cell population has distinct subtypes, such as stem-like memory CD8POS T cells, which have self-renewing capabilities, and effector-like CD8POS T cells, which carry out cytotoxic functions targeting cells presenting tumor Ags.55 We observed the expression of signature genes TCF7 (encoding TCF-1) and HMP19 (encoding NSG2) in naive and stem-like CD8POS T cells. The gene discussed is CD4; the disease is neoplasm.