CD4 and neoplasm: Survival analysis of CT-2A tumor-bearing mice treated i.t. with rIL-12 and intravenously (i.v.)with anti-CD4, anti-CD8, or anti-NK1.1 revealed that only CD8 T cell depletion significantly reduced the rIL-12-mediated anti-GB response compared with the control (IgG) (Figure 2H).