Indeed, the scRNA-seq datasets (Tnfrsf9 in Figures 3C, S4D, S4E, and S4G) indicate that, next to Ccr7POS DCs, CD8POS T cells66,67 might express the co-stimulatory receptor 4–1BB.68 This suggests that stimulation by the 4–1BBL can be provided by intratumoral Ccr7POS DCs at the tumor site (Tnfsf9 in Figures 3B and S4F), which could potentially act on both CD8POS T cells and adjacent DCs, thereby strengthening the anti-tumor response. The gene discussed is TNFSF9; the disease is neoplasm.