Single-cell RNA sequencing (scRNA-seq) analysis of human gliomas (Table S2), encompassing WHO grades II, III, and IV gliomas as well as both IDH 1 and 2 mutant and GB IDH-WT,2 suggests that the limited predictive value of IL12A/B-associated survival may be due to its low expression across human gliomas (Figure S1B). This evidence concerns the gene IL12A and central nervous system cancer.