2020). Our findings refine this model, demonstrating that ZDHHC20 regulates CCR7 on naive CD8^+ T cells, a chemokine receptor critical for lymphocyte trafficking and neuroimmune communication (Reina‐Campos et al. 2021). This immune mediation suggests that ZDHHC20’s palmitoylation activity extends beyond synaptic proteins to immune modulators, potentially amplifying neuroinflammation and disrupting synaptic pruning—a hallmark of schizophrenia. Here, ZDHHC20 is linked to schizophrenia.