ZDHHC20 and schizophrenia: 2023). Similarly, our data suggest that ZDHHC20 may amplify inflammatory cascades through CCR7‐mediated T‐cell activation, exacerbating schizophrenia risk. This aligns with emerging evidence of peripheral immune dysregulation in schizophrenia, where chronic inflammation may disrupt brain‐immune crosstalk, worsening neurodevelopmental and degenerative processes (Du et al. 2024). The specificity of ZDHHC20’s immune role merits further investigation, particularly relative to other ZDHHC enzymes, to clarify its unique contribution to schizophrenia pathology.