As previously reported, HDAC inhibitors could increase the sensitivity of gefitinib and induce cancer cell apoptosis by up‐regulating the level of BIM and activation of caspase‐3,[44] we also found this phenomenon by MS‐275 or GM‐protac treatment in H1975‐OR cells shown in Figure 5A,B. The gene discussed is BCL2L11; the disease is cancer.