Using SOMI-0 as the reference, the core model (Model 1) including age and APOE4 status found that SOMI-3/4 (HR = 3.73, CI = 1.58 – 8.79, p = 0.016 after correction) was significantly associated with incident cognitive impairment after multiple testing correction. The gene discussed is APOE; the disease is Cognitive impairment.