WWTR1 and neoplasm: The function of downstream transcriptional cofactors yes-associated protein (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ/WWTR1), regulates the expression of EMT-related transcription molecules, thus HIPPO pathway deregulation might induce changes that modify the physiological function of the niche pushing it towards a tumor microenvironment phenotype [11, 12].