STING1 and neoplasm: This combined treatment of radiotherapy and DMPtNPS@cGAMP resulted in durable complete tumor regression at the primary site and a strong abscopal effect at distant sites in a rectal cancer model.[64] These studies collectively highlight the potential of integrating STING agonists with radiosensitizers to redefine cancer treatment paradigms, offering a compelling strategy that redefines the benchmark for synergistic cancer treatment strategies, paving the way for novel radiotherapy‐immunotherapy combinations.