Synchronously, NIR‐induced Zn2+ release further enhanced cGAS enzymatic activity via metalloimmune effects.[119b] Notably, the combined cascade STING activation by DZ@A7 under NIR irradiation promoted the maturation of DCs, enhanced tumor infiltration of CTLs , and significantly attenuated both primary and metastatic 4T1 tumor growth compared to monotherapies.[119b] These findings highlight the substantial potential of NIR‐driven STING activation and synergistic PDT‐metalloimmunotherapy in nano‐based cancer treatment. Here, CGAS is linked to neoplasm.