Simultaneously, the high GSH concentrations in the TME triggered disulfide bond cleavage, releasing MSA‐2 and activating the STING pathway, thereby further amplifying tumor immunogenicity.[124c] In a bilateral flank 4T1 breast cancer model, PSPA demonstrated superior therapeutic efficacy by significantly improving survival and reducing tumor recurrence compared to either sono‐irradiation or MSA‐2 treatment alone. The gene discussed is TPO; the disease is neoplasm.