Following intravenous administration, DOX released at the tumor site induced DNA damage and activated the cGAS pathway, while Mn2+ synergistically potentiated the cGAS‐STING signaling cascade.[52a] As a result, treatment with PL/APMP‐DOX NPs in a murine breast cancer model significantly enhanced the tumor infiltration of DCs, activated tumor‐infiltrating CD8+ T cells and NK cells, and demonstrated robust chemo‐immune synergy through DOX‐induced STING activation and Mn2+‐mediated STING signaling potentiation.[52a]. The gene discussed is CD8A; the disease is breast cancer.