developed a multifunctional nanovesicle (GP@DMX NV) by encapsulating the STING agonist DMXAA into plant‐derived nanovesicles from the roots of Glycyrrhiza uralensis Fisch, followed by surface modification with PD‐L1 antibodies via DSPE‐PEG conjugation.[73a] Intratumoral administration of GP@DMX NV in the B16‐F10 melanoma model significantly remodeled the TME, promoting DC maturation and CD8+ T cell infiltration. This evidence concerns the gene CD8A and melanoma.