STING1 and neoplasm: Simultaneously, the high GSH concentrations in the TME triggered disulfide bond cleavage, releasing MSA‐2 and activating the STING pathway, thereby further amplifying tumor immunogenicity.[124c] In a bilateral flank 4T1 breast cancer model, PSPA demonstrated superior therapeutic efficacy by significantly improving survival and reducing tumor recurrence compared to either sono‐irradiation or MSA‐2 treatment alone.