Compared to conventional liposomes, LNDs demonstrated superior tumor penetration and facilitated effective intracellular delivery of STING agonists.[39] Notably, a single dose of LND‐CDNs was sufficient to activate STING and induce robust antitumor immunity across various cancer models, including the aggressive orthotopic 4T1 breast cancer and MC38 colorectal cancer models. The gene discussed is STING1; the disease is cancer.