The mild heat generated by FeS2 nanoparticles induced ICD and improved the Fenton reaction, which led to direct tumor cell killing and cGAS activation.[114e] Furthermore, PTT‐mediated heat at the tumor sites facilitated the on‐target release of cGAMP from the thermo‐sensitive liposomes, further amplifying cGAS/STING signaling activation. This evidence concerns the gene CGAS and neoplasm.