An example that highlights the synergistic potential of platin‐based drugs and STING agonists in combined cancer immunotherapy was reported by Fan et al., who developed Mn‐doped mesoporous silica nanoparticles (MM) featuring an acidity/redox‐responsive metal‐organic framework (MOF, ZIF8) as a functional gate.[53] The nanoparticles were co‐loaded with cisplatin, Mn2+, and the STING agonist SR‐717 to enable cascade activation of the cGAS‐STING pathway. Here, CGAS is linked to cancer.