This, in turn, triggers the recruitment and activation of TANK‐binding kinase 1 (TBK1), which then phosphorylates key transcription factors, including interferon regulatory factor 3 (IRF3) and nuclear factor‐kappa B (NF‐κB).[4] Activation of these pathways culminates in the production and secretion of type I interferons (IFN‐I) and other proinflammatory cytokines, which play a pivotal role in the propagation of cancer immunity. This evidence concerns the gene IRF3 and cancer.