developed self‐degradable nanoparticles composed of poly(β‐amino ester)s (PBAEs) to co‐deliver the STING agonist 2′3’‐cGAMP and the OVA antigen for B16F10‐OVA melanoma immunotherapy.[100c] PBAEs were selected due to their biocompatibility, structural versatility, ability to bind nucleic acids electrostatically, and intrinsic endosomolytic properties, making them highly suitable for gene and drug delivery applications. The gene discussed is STING1; the disease is melanoma.