Within tumor cells, the nanoparticles decomposed to release dsDNA, Mn2+, and DOX, thereby enhancing STING pathway activation and triggering a strong antitumor immune response.[52b] More importantly, the NPs effectively decreased tumor growth in both 4T1 and B16‐F10 models and prolonged survival rates, demonstrating significant potential for synergy between chemotherapy and STING agonist‐based immunotherapy.[52b]. Here, STING1 is linked to neoplasm.