CFTR inhibitor‐172 (CFTRinh‐172), an allosteric inhibitor that targets the cytoplasmic face of CFTR, slows cyst growth in PKD mice and in vitro models.[59, 60] Interestingly, a significant decrease in the size of kidney organoids was observed with CFTRinh‐172 at 50 and 100 μm, particularly in hypoxia‐stimulated organoids with relatively high CFTR mRNA expression, but not in the normoxic kidney organoids (Figure 7G,H). This evidence concerns the gene CFTR and cyst.