For instance, studies in BC cell lines demonstrate that Bik’s subcellular localization differs across stages: in MCF-7 cells (pre-metastatic), Bik is cytosolic and translocates to the nucleus on cisplatin exposure; in MDA-MB-231 cells (metastatic), Bik is nuclear and remains so despite oxidative stress; and in MCF10 cells (normal), Bik remains cytosolic [80]. The gene discussed is BIK; the disease is breast cancer.