Finally, the upregulation of B-cell lymphoma 6 (BCL6), one of the top 20 upregulated genes in SM breasts, could be a defense mechanism of the tissue against oxidation; indeed, Kurosu et al. [105] reported that BCL6 overexpression was found to reduce oxidant-induced apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.