ORAI1 and breast cancer: It is worth noting that ATPase secretory pathway Ca2 + transporting 2 (ATP2C2), a gene encoding Ca2+-ATPase SPCA2 (SPCA2) protein, was upregulated not only in SM but also in WB and WS breasts, where SPCA2 expression potentiated Ca2+ influx through Orai1 channels in breast cancer-derived cells and human breast tumors [69], suggesting that overexpression of this protein may participate in Ca2+ influx responsible for apoptosis in myopathies.