For example, some of the most recurrent coding neomers were the result of either the Gly12Asp, Gly12Val, or Gly12Cys missense mutation in the KRAS proto-oncogene GTPase (KRAS), which are known to make up 80% of cancer-associated KRAS mutations and lead to KRAS being constitutively active39,40. Here, KRAS is linked to cancer.