When patients with cblC deficiency during stable periods, the median OHCbl dosage was 1.18 mg/kg/week, which was 0.31 mg/kg/week and 1.37 mg/kg/week, respectively in patients who carried the c.482G > A variant and not. The gene discussed is CBLC; the disease is hyperinsulinemic hypoglycemia, familial, 4.