In contrast, a CD123/CD3 T cell engager, used as a positive control, demonstrated a much stronger (10- to 100-fold) induction of cytokine release, notably inducing more than 1000 pg/mL of the proinflammatory, CRS-associated cytokines IFN-γ, IL-6, and TNF39. The gene discussed is IL3RA; the disease is congenital rubella syndrome.