Human BM-MSCs significantly reduce oxidative stress and inflammation in IL-10 KO mice.158 Human BM-MSCs mediate these effects via the modulation of T cells and macrophages, and the long-term efficacy of BM-MSCs in mediating anti-inflammatory macrophages occurs via efferocytosis.159 P-MSCs, which are associated mainly with tyrosine metabolism, can also be used to treat CD mice effectively on the basis of serum metabolomics results.160 UC-MSCs can improve CD scores and attenuate the polarization of M1 macrophages.161. This evidence concerns the gene IL10 and Cowden disease.