For example, infused IFNγ-pretreated MSCs effectively protected mice against lethal acute radiation syndrome but failed to protect mice with GVHD.79 It has been reported that co-transplanting MSCs with hematopoietic stem cells reduces the incidence of aGVHD; however, many results have shown no significant difference compared with the historical control group.80 Here, IFNG is linked to graft versus host disease.