One study suggested that human G-MSC treatment alleviated atherosclerosis through decreasing monocytosis and modulating the activation and differentiation of macrophages in ApoE−/− mice.333 Lin et al.334 found that BM-MSCs secreted IL-10, TGF-β, and PGE2 to promote the Treg differentiation by upregulating Foxp3 on the T lymphocyte surface, resulting in a favorable profile of immune components in plaques. The gene discussed is APOE; the disease is atherosclerosis.