In an EAE rodent model of MS, P-MSCs and P-MSC-EVs promoted myelin regeneration by inducing endogenous oligodendrocyte precursor cells to differentiate into mature myelinating oligodendrocytes.371 Intravenous injection of P-MSCs significantly ameliorated the MS course and reduced brain inflammation and neuronal degeneration in rats, which may be related to the release of BDNF, NGF, and neurotrophic factor 3 (NTF3) by P-MSCs.372. This evidence concerns the gene NGF and myeloid sarcoma.