IFNG and Alzheimer disease: Tetramethylpyrazine-stimulated human UC-MSCs significantly ameliorated MS, by attenuation of inflammation and demyelination.368 In a chronic MS model, intravenous administration of AD-MSCs and AD-MSC-EVs attenuated induced EAE by reducing T cell proliferation, mean clinical score, and demyelination.369 AD-MSCs increased the number of splenic Tregs and decreased IFN-γ secretion and cellular infiltration in the brain, thereby improving the severity of clinical scores in an EAE mouse model.370