MAPT and Alzheimer disease: UC-MSCs can repair damaged neuronal cells and significantly improve the learning memory and cognitive ability of AD model animals by regulating tau protein phosphorylation.378 BM-MSCs have a significant effect on the tau cell death cascade and can ameliorate the toxic effects of misfolded truncated tau.379 Multiple injections of BM-MSCs in young 3xTg-AD mice significantly decreased the pathological phosphorylation of tau at T205, S214, and T231.380