Piezo1 in Il7r-expressing cells exacerbated IL-33-induced airway hyperresponsiveness, suggesting a protective role for Piezo1.50 In contrast, our study employed an inducible deletion model targeting mature ILC2s and revealed a cell-intrinsic role for Piezo1 in enhancing mTOR-dependent translation and effector function. The gene discussed is PIEZO1; the disease is airway hyperresponsiveness.