PIEZO1 and Bloom syndrome: In the BLM model, repeated administration of bleomycin leads to progressive fibrosis driven in part by ILC2-derived IL-13, which promotes fibroblast activation and extracellular matrix deposition.39,40 Piezo1 cKO mice showed accelerated recovery from weight loss (Fig. 5h) and markedly reduced fibrotic areas, as shown by Masson’s trichrome staining (Fig. 5i) and α-SMA immunofluorescence (Fig. 5j).