In the analysis for overall BC risk focusing on LoF variants, we found significant associations with BRCA1, BRCA2 and PALB2, with ORs (95% CI) of 24.9 (6.1–102.5), 7.0 (3.5–14.0), and 6.5 (3.2–13.1), respectively. Here, BRCA2 is linked to breast cancer.