In a rat CKD model, it protected the kidneys by inhibiting ERS in RTEC and inducing autophagy, suppressing NLRP3 inflammasome activation induced by lipopolysaccharide and ATP, lowering serum creatinine, and alleviating pathological damage such as tubular dilation, glomerular atrophy, and interstitial inflammatory cell infiltration [175]. Here, NLRP3 is linked to chronic kidney disease.