SNAP25 and Behcet disease: Synaptic pathology and changes in vesicle trafficking and synaptic protein levels were attributed to BD and SCZ, with findings in part divergent dependent on the brain region examined.17, 19 Pilot studies applying quantitative immunoblot to CSF samples found SNAP-25 to be increased in SCZ and unchanged in BD,20 21 in line with current findings, while levels in first episode psychosis were unchanged.22