Functional homology between FAM111A and FAM111B has been reported,16 however FAM111A dominant missense variants give rise to very different clinical phenotypes without dermatological involvement, such as Kenny-Caffey syndrome type 2 (MIM: 127000) and Gracile bone dysplasia (MIM: 602361). The gene discussed is FAM111A; the disease is osteocraniostenosis.