These notably include Rothmund-Thomson syndrome (caused by biallelic variants in ANAPC1, RTS1 [MIM: 268400]; RECQL4, RTS2 [MIM: 618625]; CRIPT, RTS3 [MIM: 615789]; DNA2, RTS4 [MIM: 620819])1,3,4 Kindler syndrome (FERMT1, MIM: 173650),5 poikiloderma with neutropenia (USB1, MIM: 604173),1,6 or inflammatory poikiloderma with hair abnormalities and acral keratoses (LTV1, MIM: 620199).7 This evidence concerns the gene DNA2 and Rothmund-Thomson syndrome.