...I had a biopsy for possible recurrence or radiation necrosis...I believe it was the T2-FLAIR that kept growing, that kept getting bigger and bigger...I have the low-grade astrocytoma grade two with the IDH1 mutation, and I would really like to know what the rhyme or reason is [that may cause LGG recurrence]. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).