Because iron levels are elevated in patients with HAND and iron influences redox homeostasis [33–35], we extended our studies by determining the extent to which gp120 and morphine alone and in combination as well as iron supplementation induces neural cell death, and affects levels of Fe2+ and the RSI in endolysosomes, cytosol, and mitochondria. Here, ITIH4 is linked to HIV-associated neurocognitive disorder.