Pan-cancer analysis showed that FDPS was significantly highly expressed in HCC, bladder cancer, breast cancer, colon cancer, esophageal cancer, head and neck squamous cell carcinoma, renal clear cell carcinoma, lung adenocarcinoma, non-small cell lung carcinoma, gastric adenocarcinoma and endometrial cancer. This evidence concerns the gene FDPS and head and neck squamous cell carcinoma.