The results showed that MY019(FC ≈ 2.0), DNA2(FC ≈ 2.3) and FDPS(FC ≈ 1.9) were significantly highly expressed in the human hepatocellular carcinoma cell line Hep3B2.1-7 compared to LO2 in normal human hepatocytes (Fig 4C, P < 0.05). This evidence concerns the gene TPRKB and hepatocellular carcinoma.