Our analysis indicates that seven risk proteins were previously identified as biomarkers (CD40, CRP, PTPN2, PTPN22, AIRE, SLC8A3, and CDC25B) and therapeutic targets for RA, while 11 risk proteins (TNFRSF1A, IL1R1, IL6ST, TGF-β1, IRAK1, SH2B3, AIM2, IRF8, PTPN11, MED1, and PLD4) have been recognized for their involvement in disease progression. This evidence concerns the gene IRF8 and rheumatoid arthritis.