In case of the MT-ATP6 gene, among the identified 8 mutations, the m.8744T > G mutation was higher in COVID-19-positive individuals than healthy controls (p = 0.009 < 0.05) and showed a significant correlation with the disease: OR (95% CI) = 24.04 (2.81–205.62). This evidence concerns the gene MT-ATP6 and COVID-19.