A subanalysis from the RE-LY study (Randomized Evaluation of Long-Term Anticoagulation Therapy), which was initially designed to investigate the appropriateness of dabigatran in comparison of warfarin, investigated the role of elevated cardiac troponin I in a preselected cohort of patients with new onset AF and found that cTnI serum levels were indepenently related to stroke [40]. This evidence concerns the gene TNNI3 and stroke disorder.